“Platform for ultra-sensitive Point-of-Care diagnostics for Infectious Diseases”

The aim of the PoC-ID project is to develop new micro- and nanoelectronic-based sensing and integration concepts for advanced miniaturized in vitro diagnostic devices. The project addresses the increasing demand for rapid and sensitive point-of-care diagnostics to reduce healthcare costs and increase the quality of life with a focus on infectious diseases, one of the world’s leading causes of morbidity and death. Interdisciplinary collaboration using the technology and expertise of the consortium members will be applied to develop and test a PoC prototype for the diagnosis of respiratory syncytial virus (RSV) infections and host responses in the pediatric context. The platform technology can be adapted to a variety of diagnostic or biosensing purposes, such as in health/environmental monitoring or food quality testing.

PoC-ID will combine the detection of both pathogens and host responses leading to more accurate diagnosis as compared to the current standard which is focused on detection of pathogens only. This novel approach will support prevention and control of pathogen spread and enable faster and more personalized patient treatment. Improved performance in terms of robustness, sensitivity and selectivity will be reached by a combination of innovative nanomembrane technology, capture molecules and two novel sensing concepts. Further advances will be realized in terms of usability and speed of data-analysis arising from the integration of sensors, read-out electronics and microfluidics into one user friendly point-of-care (PoC) platform. Costs of the new disposable sensors will be low at high volumes, thanks to designing into microelectronics production flows.